Double X Science - It's In Your Genes

Search Results for: label/immune system

  • Leaky gut and wonky immune response might be double whammy leading to inflammatory bowel disease (in mice)

    A case of ulcerative colitis, a form of inflammatory bowel disease.Photo via Wikimedia Commons. Credit: Samir. A two-hit punch in the gut might explain why some people find themselves alone among their closest relatives in having inflammatory bowel disease (IBD). The double gut punches come in the form of a compromised intestinal wall coupled with a poorly behaved immune system, say Emory researchers, whose work using mice was publishe…

    Authored by on September 13, 2012

  • Gluten sensitivity

    …ple with celiac disease, the glue doesn’t hold. Gluten fragments can sneak through these gaps and provoke an adaptive immune response that damages the intestinal lining (the full mechanism is described in great detail in this 2009 Scientific American article). The second type of gluten-induced condition, wheat allergy, is also mediated in part by the adaptive immune system. In this condition, gluten results in synthesis of IgE antibodies that cau…

    Authored by on March 15, 2013

  • The Amazing Antibody and its Therapeutic Potential

    …ll recognize and attach itself to the invader, which is scientifically referred to as an antigen.  When an antibody attaches to an antigen, it signals to our body to get rid of it.  Amazingly, each antibody can only recognize 1 antigen, which is why we need so many different types of antibodies!      To get a better idea of how antibodies work, it is important to learn their basic structure.  Antibodies are ‘Y’ shaped proteins, and have both co…

    Authored by on October 12, 2012

  • Do fecal bacteria from face mites cause rosacea?

    …DF], which is drawn to your sebaceous (oil) glands, also on your face. Because they have “piercing-sucking mouth parts,” pedipalps, and eight legs in four pairs, according to one lovingly detailed description in a 1976 paper, they are arachnids, just like spiders. Tiny arachnids that live on your face, taking moonlit strolls when it’s dark and diving for cover in light. They live there, just as you live in a house, except your f…

    Authored by on September 6, 2012

  • Biology Explainer: The big 4 building blocks of life–carbohydrates, fats, proteins, and nucleic acids

    …molecules themselves break down into a surprisingly small number of building blocks. The proteins that make up all of the living things on this planet and ensure their appropriate structure and smooth function consist of only 20 different kinds of building blocks. Nucleic acids, specifically DNA, are even more basic: only four different kinds of molecules provide the materials to build the countless different genetic codes that translate into all…

    Authored by on June 8, 2012

  • Depressing genes

    Can depression be a matter of genetic fate? by Siobhan Mitchell          [This post is the latest installment in our I Am Mental Illness series.] What if you could know if you were fated to be depressed? With the rise of personal genotyping services such as 23andme, almost can find out what their psychiatric ‘fate’ will be, but what do you do with this information once you have it? When I first considered testing myself for depressio…

    Authored by on May 17, 2013

  • Towards better drug development, fewer side effects?

    …on’t worry –- the article is way more interesting than its title.  Those trees on the right are called SPADE trees. They map cellular responses to different  stimuli in a collection of human blood cells. Credit: (c) 2012 Nature America [Nat Biotechnol, 30:858--67, 2012] Here’s the basic idea: The current methods drug developers use to screen potential drug compounds –- typically a blend of high-throughput imaging and biochemical ass…

    Authored by on September 24, 2012

  • After Newtown missteps, journalists get guidelines

    …almost twice as likely to say that they don’t want to live or work near a person with mental illness if they read an article about a person with mental illness involved in a mass shooting, according to a study published March 20 in the American Journal of Psychiatry. Interestingly, this tendency is the same even if the article avoids any mention of mental illness. This may be because this link between violence and mental illness is deeply engrain…

    Authored by on March 27, 2013

  • From spiders to breast cancer: Leslie Brunetta talks candidly about her cancer diagnosis, treatment, and follow-up

    …very giving. I live in Cambridge, MA, where I could actually make choices about where I wanted to be treated at each phase and know I’d get excellent, humane care and where none of the facilities I went to was more than about 20 minutes away. Some things that women might have some control over and that their families might help nudge them toward: Find doctors you trust. Ask a lot of questions and make sure you understand the answers. But do…

    Authored by on January 31, 2012

  • Creating viruses to create the vaccines?

    Synthetic viruses could mean a faster flu vax. by Carrie Arnold     In 2009, scientists scrambled to develop a vaccine against the H1N1 influenza pandemic. Although the first cases of illness were reported in March, a vaccine wasn’t ready in the U.S. until late September — a lag of almost seven months. Large amounts of vaccine weren’t available until several months after that. By then, the second wave of infections had peaked, as had much…

    Authored by on May 20, 2013

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