
Category Archives: Physics
The 2013 Flame Challenge Question: What is time?
By Biology Editor Jeanne Garbarino
The Bright Crystal
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| The crazy-complicated structure of the ribosome, solved by x-ray crystallography (Source) |
… a method of determining the shape and structure of things that we can’t see with our own eyes. Imagine that you have captured Wonder Woman’s invisible airplane. You can’t see it. But you know it’s there because when you throw a rubber ball at the space, the ball bounces back to you. If you could throw enough rubber balls, from all different sides, and measure their trajectory and speed as they bounced back, you could probably get a pretty good idea of the shape of the plane.
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| (Source) |
The first development was the commissioning in the past few years of ultra-bright x-ray sources in California (the Linac Coherent Light Source at Stanford) and Japan. These so-called “x-ray free electron lasers” (X-FELs) shoot incredibly bright, incredibly short x-ray pulses, pulses that are so intense that they destroy a sample in a fraction of a second, but not before the x-rays (which travel at the speed of light, natch) have bounced off of it.
The reason crystals are required in crystallography is that any one diffraction event is hard to see. The regularly spaced molecules inside a crystal amplify that relatively weak signal, simplifying detection and structure determination. As it turns out, the brighter an x-ray source, the smaller the crystal required to obtain such data has to be, and with X-FELs, the crystals can be very small indeed – on the order of millionths of a meter (micrometers) in size, and perhaps even smaller.
Which brings me to the second development. In the March issue of the journal Nature Methods, a team of researchers led by Michael Duszenko in Germany showed that some proteins that cannot crystallize in a test tube will crystallize inside insect cells. Protein chemists often use cells as molecular factories to obtain large quantities of protein. But the goal is to extract the protein from the cells, not have them crystalize inside of them. Generally speaking, protein crystallization inside cells is a bad thing, the kind of thing researchers really don’t want to see; Duszenko and his team are the first to capitalize on this so-called “in vivo crystallization” phenomenon.
The crystals Duszenko’s team collected are quite small, of course –- they fit inside cells, after all — and in that initial study, they were on the order of 1 micrometer wide and 15 micrometers long. But as it turns out, they are big enough for the X-FEL. In the March paper, the team showed that these crystals will diffract x-rays in the X-FEL, but they didn’t solve the resulting structure.
Now, in a paper published Nov. 29 in Science, they have. They did it by combining X-FEL and in vivo crystallization to solve the structure of a trypsanosomal enzyme called cathepsin-B, a potential drug target for African sleeping sickness.
The team sprayed a stream of tiny enzyme crystals (each about 1 x 1 x 11 micrometers) into the path of the X-FEL, which fired discrete pulses of x-ray, each just 40 femtoseconds, or 0.000000000000040 seconds long, 120 times per second. Every so often, one of those pulses would collide with a crystal, and a nearby camera would capture the event.
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| Serial femtosecond crystallography (Source Continue reading |
A Few Modern Physicists
by Adrienne M. Roehrich, Chemistry Editor
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| Vandana Shiva in 2008. |
| Ingrid Daubechies, 2005. |
Ingrid Daubechies is a physicist and a mathematician known for her work in wavelets.
The Steele Prize is awarded for cumulative work of mathematical contribution to the field.
The NSF Career Award is a highly competitive grant awarded to early career scientists.
Alfred P. Sloan Fellowships are awarded to distinguished scholars with high potential for impact in their respective fields.
The Maria Goeppert-Mayer Award recognizes outstanding achievement by a woman physicist in the early years of her career.
The opinions expressed in this post do not necessarily agree or conflict with those of the DXS editorial team and contributors.
Frankenstorm: What is the role of climate change?
I’ve seen this question crop up a lot over the last few days-it’s a natural one, I’d think, given promises of more frequent extreme weather events in association with human-driven global climate shifts: What is the role of climate change, if any, in Sandy the Frankenstorm, currently bearing down and flooding the US northeast after having killed dozens in the Caribbean on her way to US shores?
While the echo of Frankenstein in that Twitter moniker can imply this is a human-created meteorological monster, it’s just not that simple.
But there remains far too much natural variability in the frequency and potency of rare and powerful storms — on time scales from decades to centuries — to go beyond pointing to this event being consistent with what’s projected on a human-heated planet.
By Emily Willingham
The opinions expressed in this post do not necessarily conflict with or represent those of the DXS editors or contributors.
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FYI: For updates on this sort of analysis and what’s happening with Sandy in real time, the folks at Boing Boing tweeted this list of recommended people to follow on Twitter.
Update 2:30 ET: Check out this beautiful, mesmerizing, and scary wind map, made with data on surface winds from a national database.
As Seen on TV! Restoring Hair with LASERS!!!!!!
The author’s rapidly-expanding forehead. Anyone who watches TV, reads magazines, or flips through catalogs has seen some interesting products. Maybe they seem plausible to you, maybe they don’t. However, a little investigation shows they are based less on science and well…actually working, and more on wishful thinking. At worst they’re actual con-jobs, designed to separate you from your money as efficiently as possible (which I guess is a certain standard of success). As a result, we at Double X Science bring you “As Seen on TV!” In these features, we’ll look at some of the products shilled on talk shows and infomercials, items lurking between the articles you read in magazines, or things you might find on the shelves of the stores where you shop.
Night on Baldhead Mountain
Lasers (without sharks)
The smell of frying follicles
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| The author engages in home laser hair restoration, while his cats meow around his feet. |
- Hair loss in its most common forms is hormonal, so it’s unclear to me that light (whether laser or otherwise) has anything to do with it. Hair removal can be achieved with lasers, but that involves causing damage to hair follicles, not using anything intrinsic to light.
- Lasers are simply very monochromatic light sources, that use synchronization of atoms on the microscopic level to do their business. There’s nothing in a laser that isn’t in ordinary light bulbs, though you can make things far more intense with a laser. However, high intensity brings us back to laser hair removal, not restoration.
- As always, if a product sounds miraculous, it’s probably bunkum. If all it took to regrow hair was a glorified laser pointer, nobody would be bald! LED lasers are cheap and ubiquitous; we could all restore our hair without paying a company $700 (and listen to the music on inexpensive headphones, to boot).
Drill, baby, drill — microbial-style
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| Could the oil energy needed to light up this drill come directly from soil bacteria instead of the soil? Image credit: Obakeneko; via Wikimedia Commons |
By Jeffrey Perkel, DXS tech editor
It’s no secret that America’s petroleum addiction is a problem in need of a solution. “Drill, baby, drill” notwithstanding, this country eventually will have to find a way to survive without low-cost oil – or at least, find another way to make it.
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| Ralstonia eutropha bacteria in culture |
… in the microbe’s natural state, when its source of essential nutrients such as nitrate or phosphate is restricted, “it will go into carbon-storage mode,” [Brigham says,] essentially storing away food for later use when it senses that resources are limited.
“What it does is take whatever carbon is available, and stores it in the form of a polymer, which is similar in its properties to a lot of petroleum-based plastics,” Brigham says. By knocking out a few genes, inserting a gene from another organism and tinkering with the expression of other genes, Brigham and his colleagues were able to redirect the microbe to make fuel instead of plastic.
Double Xplainer: Once in a Blue Moon
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| Full Moon, from Flickr user Proggie under Creative Commons license. |
The Moon and the Sun Don’t Get Along
Work-Life Balance for Whom?
Today we are grateful to Athene Donald for allowing us to repost her piece on work/life balance. This post originally appeared on her blog, Athene Donald’s Blog, in July of this year.
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| (Source) |
Welcome to the 21st century and welcome to MARS
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| Parachutes and SKY CRANES! Image credit: NASA. Woohoo, NASA! |
Update: Check out below what you see in the above graphic, except that it’s a real image of the real rover with its real parachute, heading for the surface of Mars! Image by way of the Bad Astronomer, a.k.a., Phil Plait.
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| Via NASA. |















